Structure Therapeutics GLP-1 pill cuts blood sugar, weight in early diabetes study

Structure Therapeutics said Monday that its experimental GLP-1 pill demonstrated a 1% lowering of blood glucose and slightly more than 3% weight loss relative to a placebo in a 12-week study involving participants with type 2 diabetes — results that are preliminary but don’t quite match a competing oral drug under development by Eli Lilly.

The Structure drug, called GSBR-1290, may have a tolerability advantage: Only one participant out of 36 dropped out of the study due to drug-related side effects — a 2.8% discontinuation rate that could prove to be an advantage if confirmed in larger studies.

GSBR-1290, taken once daily, belongs to the booming class of GLP-1 drugs that increase insulin production to lower blood sugar in people with diabetes and make people feel full after eating, leading to dramatic weight loss in people with obesity.

STAT+ Exclusive Story

Already have an account? Log in

This article is exclusive to STAT+ subscribers

Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+.

Already have an account? Log in

Already have an account? Log in

Individual plans

Group plans

Monthly

$39

Totals $468 per year

$39/month Get Started

Totals $468 per year

Starter

$30

for 3 months, then $39/month

$30 for 3 months Get Started

Then $39/month

Annual

$399

Save 15%

$399/year Get Started

Save 15%

11+ Users

Custom

Savings start at 25%!

Request A Quote Request A Quote

Savings start at 25%!

2-10 Users

$300

Annually per user

$300/year Get Started

$300 Annually per user

View All Plans

Get unlimited access to award-winning journalism and exclusive events.

Subscribe

Log In